A burn patient receives a skin graft; immunosuppressants prevent rejection. Which mechanism limits collagen synthesis, delaying wound healing, despite the graft?

💡 Explanation

Collagen synthesis requires hydroxylation of proline residues via prolyl hydroxylase; impaired activity limits stable triple helix formation. Immunosuppressants can inhibit this enzyme. Therefore, reduced prolyl hydroxylase limits collagen production, rather than growth factor signaling or TGF-beta.

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