A patient undergoes prolonged corticosteroid therapy; which consequence becomes most likely due to the reduced synthesis of dermal components?

💡 Explanation

Corticosteroids inhibit collagen synthesis and reduce its cross-linking, thus reducing wound strength. Impaired collagen cross-linking during repair results because corticosteroids suppress prolyl hydroxylase, an enzyme essential for collagen maturation; therefore, impaired repair is the consequence, rather than accelerated fibroblast proliferation or enhanced melanocyte activity, which are not directly suppressed.

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