A patient with advanced liver cirrhosis experiences significantly impaired detoxification. Which effect dominates because the liver's ability to perform phase I and phase II biotransformation reactions is compromised?

💡 Explanation

Liver cirrhosis impairs detoxification, so the liver's ability to metabolize drugs is reduced because hepatocytes are damaged; therefore, drug half-lives are prolonged, rather than being shortened by efficient metabolism, as is the case in a healthy liver.

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