A patient with asthma uses a beta-agonist inhaler during an attack; which mechanism explains why bronchodilation occurs more slowly if inflammation chronically elevates histamine levels in the bronchioles?

💡 Explanation

Chronic histamine exposure can lead to desensitization of smooth muscle cells to beta-agonists because the continuous stimulation alters receptor signaling. Therefore, bronchodilation is slower, rather than having a receptor binding issue or an increase in the cAMP cascade from the beta-agonist.

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