A person experiences increased hunger despite normal caloric intake; which mechanism explains this phenomenon in relation to ghrelin?

💡 Explanation

Ghrelin stimulates appetite. Reduced sensitivity to ghrelin in hypothalamic neurons disrupts satiety signals, because the brain fails to respond to ghrelin's normal appetite-stimulating effect; therefore, increased hunger occurs, rather than suppressed appetite due to GLP-1, leptin effects, or vagal stimulation.

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