A researcher introduces a compound that inhibits phospholipase A2 into a cell culture stimulated with lipopolysaccharide (LPS). Which consequence follows regarding inflammation?

💡 Explanation

Phospholipase A2 is required to release arachidonic acid from membrane phospholipids, a necessary precursor for prostaglandin synthesis. Therefore, inhibiting phospholipase A2 suppresses prostaglandin production because the substrate is unavailable, rather than enhancing leukotriene or TNF-α production which use different pathways.

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