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← Human Body & HealthAn alcoholic patient with advanced cirrhosis exhibits ascites (fluid accumulation in the abdomen). Which mechanism exacerbates this condition by reducing plasma oncotic pressure within liver sinusoids?
A)Increased urea cycle activity
B)Enhanced glycogenolysis stimulation
C)Decreased bilirubin conjugation
D)Impaired albumin protein synthesis✓
💡 Explanation
Impaired albumin synthesis leads to reduced plasma oncotic pressure, because albumin is a major determinant of colloid osmotic pressure; therefore, fluid leaks into the peritoneal cavity, rather than being retained within blood vessels, as occurs with proper protein concentrations.
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