An individual with iodine deficiency consumes excessive goitrogenic foods. Which outcome is most likely in the thyroid gland?

💡 Explanation

Goitrogenic foods inhibit thyroid hormone synthesis; because iodine deficiency already limits T3/T4 production, the resulting low hormone levels cause increased TSH secretion from the pituitary, which stimulates hypertrophy of thyroid follicular cells. Therefore, hypertrophy occurs, rather than increased hormone production or suppression of thyroglobulin synthesis which are less likely under iodine-deficient conditions.

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