An mRNA vaccine elicits a stronger antibody response after a booster shot; which mechanism explains this phenomenon involving B cells?

💡 Explanation

Affinity maturation explains the improved antibody response following a booster, because repeated antigen exposure drives somatic hypermutation in B cells, selecting for higher-affinity antibodies. Therefore, the antibodies become more effective at neutralizing the virus, rather than the exhaustion of T cells suppressing proliferation.

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