An obese patient undergoes gastric bypass surgery which alters gut hormone secretion. Which mechanism explains why they experience increased satiety with smaller food portions?

💡 Explanation

Gastric bypass leads to increased secretion of GLP-1 (glucagon-like peptide 1) because the surgery exposes the distal bowel to nutrients earlier, therefore GLP-1 slows gastric emptying and promotes satiety. This leads to reduced appetite rather than changes in vagal nerve stimulation or leptin sensitivity.

• Which risk increases as prior Streptococcus pyogenes infection causes rheumatic fever?
• What happens to immune system function when regulatory T cells fail in the thymus during negative selection?
• Which failure mode becomes likely when dopamine D2 receptor density decreases in the nucleus accumbens of a cocaine user?
• A patient with liver cirrhosis exhibits prolonged bleeding after a minor cut. Which process is most impaired in this patient, leading to increased bleeding time?
• A person with opioid use disorder experiences intense craving after seeing a place associated with prior drug use. Why does this craving intensify so rapidly in this context?
• Why does sensorineural hearing loss often exhibit frequency-dependent sensitivity?