An orally administered drug undergoes significant first-pass metabolism. If the intestinal CYP3A4 enzyme is inhibited, which consequence follows?

💡 Explanation

When intestinal CYP3A4 is inhibited, first-pass metabolism decreases because the breakdown of the drug in the gut is reduced; therefore, a larger fraction of the drug reaches systemic circulation, and the bioavailability increases rather than decreases or affecting clearance or volume.

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