During a severe systemic infection, which consequence follows from excessive Interleukin-1 (IL-1) production in the liver?

💡 Explanation

IL-1, a pro-inflammatory cytokine, triggers the acute phase response in the liver, upregulating the synthesis of acute phase proteins, because this process is crucial for combating infection. Therefore, acute phase protein synthesis increases, rather than other metabolic adjustments, because the body prioritizes immune defense over homeostatic functions during systemic infections.

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