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← Human Body & HealthFollowing a booster vaccine dose, which mechanism explains why subsequent antibody response is faster and stronger, displaying enhanced neutralization of viral variants?
A)Increased innate immune activation immediately
B)Affinity maturation in germinal centers✓
C)Direct cytokine storm induction initially
D)Complement cascade inhibits viral entry
💡 Explanation
Booster vaccines stimulate affinity maturation within germinal centers of lymph nodes because this process refines antibody binding to the antigen, resulting in antibodies with higher affinity and neutralization potential. Therefore, the response is faster and stronger due to the presence of higher-affinity antibodies rather than innate activation or inhibition of viral entry.
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