Following in vitro fertilization, if the zona pellucida remains unusually thick, which consequence follows, impeding successful pregnancy?

💡 Explanation

A thickened zona pellucida hinders the physical escape of the blastocyst, which is necessary for attachment to the uterine wall; this is termed impaired blastocyst hatching. Because the mechanical impediment of the zona inhibits implantation, rather than affecting sperm or early development, therefore option D is correct.

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