If a diabetic patient experiences prolonged elevated blood glucose after a surgical wound, which consequence follows regarding collagen synthesis?

💡 Explanation

Hyperglycemia impairs the non-enzymatic glycation of collagen, a process that interferes with normal collagen cross-linking; this impairs wound healing because collagen cross-linking is vital for tensile strength. Therefore, collagen cross-linking is impaired, rather than increased fibroblastic proliferation, which would promote collagen deposition under normal conditions.

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