If a drug distributes extensively into tissues, but renal clearance remains constant, why does the elimination half-life increase significantly more than predicted solely by the change in clearance?

💡 Explanation

The elimination half-life is directly proportional to the volume of distribution because a larger volume means a lower plasma concentration for a given amount of drug in the body. Therefore, even with unchanged clearance, a larger volume prolongs elimination, rather than changes in metabolism or filtration rates affecting half-life as significantly.

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