If a drug with high hepatic extraction ratio is switched from intravenous to oral administration, which consequence follows regarding plasma concentration?

💡 Explanation

A high hepatic extraction ratio implies the liver removes much of the drug during the first pass. Because of this first-pass effect, bioavailability is drastically reduced after oral administration; therefore, the plasma concentration achieved is lower than with IV administration, rather than increased half-life or volume of distribution changes.

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