If a football player experiences a rotational head impact, which cascade explains why diffuse axonal injury occurs, exceeding cellular strain tolerance?

💡 Explanation

When rotational forces act on the brain, shear strain occurs. Because the brain tissue deforms unevenly, this strain disrupts the axonal cytoskeleton, leading to axonal injury. Therefore, cytoskeletal disruption is the correct answer, rather than ATP reversal or microglial activation, which are not direct consequences of shear strain.

• Why does blood pressure increase when blood vessels narrow?
• A woman with a history of recurrent miscarriages is prescribed progesterone suppositories during early pregnancy. Which process is being augmented to reduce miscarriage risk?
• Why does a person with damaged A-beta fibers touching rough sandpaper report diminished tactile acuity, relative to undamaged individuals?
• Why does thyroxine production remain elevated despite high circulating thyroid hormone levels in individuals with thyroid hormone resistance syndrome?
• Which risk significantly increases when thyroxine feedback disruption occurs?
• Which failure mode becomes likely when a person experiences chronic hypertension affecting the vessel walls of the afferent arterioles in the kidneys?