If a macrophage is unable to effectively clear apoptotic cells during inflammation resolution, which consequence is most likely?

💡 Explanation

Impaired clearance of apoptotic cells prevents the normal shift toward inflammation resolution, because these cells release anti-inflammatory mediators that promote macrophage phenotype switching and downregulate pro-inflammatory signals; therefore, NF-kB remains active, driving sustained cytokine release, rather than initiating the resolution phase.

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