If a mutation disables EGFR endocytosis in lung cancer cells, which consequence is most likely?

💡 Explanation

EGFR endocytosis normally internalizes and degrades the receptor, limiting signaling duration. If endocytosis is disabled, EGFR remains active at the cell surface, causing sustained signaling via the RAS/MAPK pathway that promotes uncontrolled cell proliferation and growth, because the normal regulatory mechanism is absent; therefore, cell growth is enhanced, rather than being regulated, as in options A, B and C.

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