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Human Body & Health

If a mutation in the EGFR receptor allows continuous downstream signaling, even without growth factor binding, which consequence follows regarding cancer cell proliferation?

A)Increased cell cycle arrest at G1
B)Decreased reliance on glycolysis
C)Enhanced DNA damage repair rate
D)Uncontrolled cell division and growth

💡 Explanation

Continuous EGFR signaling due to mutation bypasses normal growth factor-dependent regulation of cell division; because the receptor is always active, it promotes unregulated cell cycle progression. Therefore, uncontrolled division occurs, rather than controlled division or effects on metabolic pathways.

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