If a novel virus overwhelms the innate immune response, leading to significant cell damage, which consequence involving antigen-presenting cells (APCs) is most likely to worsen the infection?

💡 Explanation

Enhanced cross-presentation worsens outcomes because it amplifies the cytotoxic T-cell response against infected, but not yet severely damaged, cells, thus expanding viral spread. This is because cross-presentation by APCs presents viral antigens on MHC I, leading to cytotoxic T cell activation. Therefore, enhanced cross-presentation accelerates the infection rather than containing it.

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