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Human Body & Health

If a patient abruptly stops taking a stimulant medication after chronic use, which effect is most directly linked to increased craving?

A)Increased GABA receptor expression
B)Decreased serotonin transporter density
C)Elevated endogenous opioid release
D)Reduced dopamine receptor sensitivity

💡 Explanation

Reduced dopamine receptor sensitivity underlies drug craving because the brain's reward system is less responsive to normal stimuli, therefore craving is heightened as the individual seeks the drug to compensate, rather than from the other listed neurotransmitter imbalances.

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