If a patient chronically underproduces incretin hormones like GLP-1 after meals, which consequence related to blood glucose regulation is most likely to dominate?

💡 Explanation

Reduced GLP-1 leads to decreased insulin secretion because GLP-1 normally amplifies insulin release from pancreatic beta cells after a meal. Therefore, reduced postprandial insulin secretion is the dominant effect, rather than increased glycogen synthesis or enhanced insulin sensitivity, which are normally stimulated by insulin.

• A person experiences persistent muscle rigidity after prolonged exposure to an organophosphate pesticide. Which mechanism explains this effect on neuromuscular junctions?
• Why does the perceived intensity of chronic pain often decrease when a person engages in moderate exercise, even if the original nociceptive stimulus remains?
• A woman with a history of infertility is undergoing in-vitro fertilization (IVF). If the administered dose of follicle-stimulating hormone (FSH) is insufficient during ovarian stimulation, which consequence follows?
• Why does chronic psoriasis lead to weakened skin integrity and increased risk of secondary infections, despite increased keratinocyte proliferation?
• Why does fever increase heart rate, even though cardiac output could initially meet metabolic demands?
• Why does chronic morphine use lead to analgesic tolerance?