If a patient develops angioedema during surgery due to latex allergy, which consequence follows regarding histamine's role?

💡 Explanation

Systemic vascular permeability increases due to histamine release from mast cell degranulation. Because histamine binds to endothelial cells, it causes increased inter-endothelial gaps, therefore leading to fluid extravasation and edema, rather than directly acting on arterioles or inhibiting mast cells.

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