If a patient exhibits symptoms of neurodegeneration due to intracellular protein aggregate accumulation, which therapeutic approach targets the cellular mechanism most directly involved in resolving this condition?

💡 Explanation

Neurodegeneration related to protein aggregates often involves impaired protein clearance. Upregulating chaperone-mediated autophagy directly enhances the removal of these aggregates, because it facilitates their degradation. Therefore, autophagy targeted therapy is a direct approach, rather than affecting neuronal excitability or glial support.

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