If a patient has chronically elevated levels of 2,3-BPG in their red blood cells due to persistent hypoxemia from a pulmonary disease, which consequence follows?

💡 Explanation

Elevated 2,3-BPG shifts the hemoglobin oxygen dissociation curve to the right, decreasing hemoglobin's affinity for oxygen because 2,3-BPG stabilizes the T (tense) state of hemoglobin. Therefore, oxygen is more readily released to tissues, rather than hemoglobin holding onto oxygen too tightly under hypoxic conditions.

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