If a patient's distal convoluted tubule and collecting duct are impermeable to water due to non-functional aquaporins, which consequence follows regarding plasma osmolality and ADH levels?

💡 Explanation

With non-functional aquaporins, water reabsorption in the collecting duct decreases; therefore, plasma osmolality increases, triggering the hypothalamus to release more ADH to stimulate thirst and attempt to increase water retention, rather than decrease ADH secretion.

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