If a patient's immune system chronically elevates NF-κB activity in response to minor stimuli within the intestinal lining, which consequence dominates the resulting inflammatory cascade?

💡 Explanation

NF-κB activation promotes transcription of pro-inflammatory cytokines and chemokines. Because chronic activation bypasses normal regulatory controls, it leads to an overproduction of these signaling molecules. Therefore, unchecked cytokine and chemokine secretion will occur, rather than apoptosis alone or regulated barrier responses.

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