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Human Body & Health

If a patient's liver function is severely impaired, which consequence follows regarding thyroid hormone regulation?

A)Increased TSH secretion from pituitary
B)Elevated T4 levels in blood
C)Reduced iodine uptake by thyroid
D)Decreased T3 production from T4

💡 Explanation

Liver impairment reduces the activity of deiodinase enzymes, which convert T4 to the active T3 form. Because T3 production is reduced, therefore hypothyroidism symptoms may worsen, rather than increased T4 or TSH levels, which depend on thyroid function itself.

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