If a patient undergoing a kidney transplant develops immediate hypersensitivity to a previously tolerated immunosuppressant drug (e.g., after prior sensitization), which consequence is most likely?

💡 Explanation

Immediate hypersensitivity, like a drug allergy, involves sensitization leading to IgE production. Upon subsequent exposure, the drug crosslinks IgE on mast cells, triggering degranulation and histamine release, because histamine mediates allergic symptoms. Therefore, mast cell degranulation is the correct outcome, rather than metabolic changes or immune complex formation.

• Which consequence results when synovial fluid compression fails in joints?
• If an individual chronically consumes antibiotics, which consequence becomes more likely within the digestive system?
• Why does vascular resistance increase as blood vessel radius decreases, especially in arterioles?
• A patient with pulmonary fibrosis experiences significantly reduced oxygen transfer from alveoli to blood. Why does supplemental oxygen via nasal cannula only partially alleviate the hypoxemia?
• An athlete sustains a concussion; imaging shows no visible macroscopic damage. Which mechanism explains ongoing cognitive deficits despite the absence of large-scale lesions?
• An individual abruptly stops taking a prescribed hypnotic medication that enhances GABA activity to address chronic insomnia. Which consequence follows due to rapid receptor down-regulation?