If a patient undergoing physical therapy reports increased pain despite tissue healing based on MRI evidence, which mechanism explains this amplified pain perception?

💡 Explanation

Persistent nociceptor input, even after tissue healing, can lead to central sensitization. Because the spinal cord and brain become hyperexcitable, normal stimuli are perceived as painful. Therefore, the patient experiences amplified pain, rather than pain reduction due to decreased inflammation or altered neurotransmitter levels.

• Why does chronic hypertension damage the renal glomeruli?
• If a neurotoxin selectively blocks Piezo2 channels in human Pacinian corpuscles, which sensory effect follows?
• Why does a thrombus formed in deep vein thrombosis (DVT) resist initial breakdown better than a fresh superficial clot?
• If a weightlifter experiences muscle fatigue during a set, even with sufficient oxygen, which consequence follows from the rapid increase in hydrogen ions?
• If interstitial fluid pressure in lower extremities increases due to prolonged standing, which consequence follows regarding fluid balance?
• In human fertilization, what causes the initial block to polyspermy after sperm-egg fusion?