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← Human Body & HealthIf a patient with a history of iodine deficiency undergoes gastric bypass surgery, which consequence on thyroid hormone regulation is most likely?
A)Increased TSH secretion and T4 production
B)Decreased TSH secretion and T4 production
C)Reduced T4 to T3 conversion in periphery✓
D)Elevated thyroid hormone receptor sensitivity
💡 Explanation
Gastric bypass can impair nutrient absorption, including selenium, required for deiodinase enzymes that convert T4 to T3. This leads to reduced peripheral T4 to T3 conversion because less selenium impairs deiodinase activity; therefore, T3 levels decrease, rather than affecting TSH secretion directly.
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