If a patient with Hashimoto's thyroiditis takes excessive iodine supplements while also having a deiodinase enzyme deficiency, which consequence is most likely?

💡 Explanation

Excessive iodine intake can worsen hypothyroidism in Hashimoto's patients, particularly with deiodinase deficiency, because the Wolff-Chaikoff effect, a negative feedback loop, becomes prolonged due to the impaired conversion of T4 to T3. Therefore, hypothyroidism is exacerbated, rather than hormone synthesis increasing or receptor sensitivity being enhanced, because the thyroid can't effectively process the iodine.

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