If a patient with rheumatoid arthritis develops a genetic mutation causing constitutive activation of NF-κB in synovial fibroblasts, which consequence follows regarding the inflammatory prostaglandin pathway?

💡 Explanation

Constitutive NF-κB activation leads to sustained transcription of COX-2, a key enzyme in prostaglandin synthesis, because NF-κB directly upregulates COX-2 gene expression. Therefore, COX-2 enzyme expression will remain elevated, rather than being downregulated or affected in terms of phosphorylation or receptor activity.

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