If a pharmaceutical company aims to reduce chronic neuropathic pain by enhancing descending modulation, which consequence follows from stimulating the periaqueductal gray (PAG) region?

💡 Explanation

Stimulating the PAG activates descending pain modulation pathways, causing release of endorphins and enkephalins that inhibit nociceptor signal transmission in the spinal cord. Therefore, pain signals are reduced, rather than amplified, and pain thresholds are decreased rather than increased.

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