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Life Sciences & Medicine

If a pharmaceutical researcher introduces a novel molecule that selectively enhances coactivator binding to estrogen receptors (ER) within a cell nucleus, which consequence follows?

A)Decreased ER receptor mRNA transcription
B)Reduced estrogen receptor phosphorylation
C)Inhibition of receptor dimerization process
D)Increased ER-mediated gene transcription

💡 Explanation

Enhancing coactivator binding to nuclear estrogen receptors directly promotes assembly of the transcriptional complex, because this enhances the ability of the receptor to activate gene expression. Therefore, ER-mediated gene transcription increases, rather than other effects such as inhibiting dimerization which is a separate step.

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