If a researcher discovers a novel compound that selectively inhibits cyclooxygenase-2 (COX-2) in activated macrophages, which consequence follows regarding inflammatory pathways?

💡 Explanation

Inhibiting COX-2 directly reduces prostaglandin E2 (PGE2) synthesis because COX-2 is the enzyme responsible for converting arachidonic acid into PGE2. Therefore, the correct answer is reduced prostaglandin E2, rather than increased cytokine production, NF-κB activation, or leukotriene formation.

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