If a researcher inhibits phospholipase A2 (PLA2) in immune cells responding to tissue damage, which consequence follows regarding the inflammatory pathway?

💡 Explanation

Inhibiting PLA2 reduces arachidonic acid release from cell membranes, because PLA2 catalyzes this initial step in prostanoid synthesis. Therefore, arachidonic acid and downstream prostanoids like prostaglandins are reduced, rather than leukotriene production increasing or COX-2 activity rising because the substrate is absent.

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