If a researcher selectively deactivated filaggrin production in human epidermal cells cultured in vitro, which consequence is most likely?

💡 Explanation

Filaggrin is crucial for aggregating keratin filaments within epidermal cells and forming the skin barrier. Deactivating filaggrin impairs the proper assembly of this barrier because the structural integrity of the stratum corneum diminishes; therefore, barrier function declines, rather than triggering melanin synthesis or impacting collagen/sebum production directly.

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