If an asthmatic patient's inhaled corticosteroid dosage is insufficient to prevent mast cell degranulation triggered by allergen exposure, which consequence follows regarding histamine?

💡 Explanation

Histamine released from mast cells binds to H1 receptors on bronchial smooth muscle, causing bronchoconstriction; therefore, increasing mast cell degranulation increases bronchoconstriction. Corticosteroids ideally prevent this, rather than directly influencing beta-2 receptor or mucus production following mast cell activation.

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