If an individual with a suppressed immune system undergoes stem cell transplantation without thorough MHC (major histocompatibility complex) matching, which consequence follows regarding the transplanted cells?

💡 Explanation

Graft-versus-host disease develops because the donor immune cells in the graft recognize the recipient's tissues as foreign, triggering a severe inflammatory response via T-cell mediated cytotoxicity. Therefore, GVHD emerges, rather than stem cell proliferation or normal differentiation, because the immune mismatch leads to aggressive attack on recipient tissues.

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