If newly synthesized proteins aggregate in the endoplasmic reticulum because of chaperone deficiency, which consequence follows?

💡 Explanation

The unfolded protein response (UPR) is activated by ER stress due to misfolded proteins; because chaperones normally assist in proper folding, chaperone deficiency leads to the accumulation of unfolded proteins, therefore UPR is activated rather than normal protein folding and processing.

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