In a patient with chronic anemia treated with high-altitude residence to stimulate erythropoiesis, which effect dominates the hemoglobin-oxygen dissociation curve?

💡 Explanation

The Bohr effect involves pH, CO2, and 2,3-BPG influencing hemoglobin's affinity for oxygen. High-altitude residence increases 2,3-BPG production to enhance oxygen delivery, because this rightward shift decreases Hb affinity. Therefore, 2,3-BPG dominates, rather than chloride binding or a leftward shift from fetal hemoglobin.

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