In a scenario where the endometrial lining fails to thicken adequately during the menstrual cycle, which mechanism most likely disrupts successful implantation?

💡 Explanation

Successful implantation requires a receptive endometrium, and that receptivity depends heavily on progesterone signaling. Inadequate progesterone receptor signaling prevents the necessary changes in endometrial structure and function because decidualization is not sufficiently induced, therefore implantation fails, rather than being caused by other hormonal or immune factors.

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