In Alzheimer's disease, why does accumulation of misfolded amyloid-beta increase neuronal damage?

💡 Explanation

Impaired proteasome-mediated protein clearance causes a buildup of misfolded proteins such as amyloid-beta within neurons, because the proteasome system is crucial for removing damaged or unnecessary proteins. Therefore, this buildup leads to cellular dysfunction and eventual neuronal death, rather than neurotransmitter alterations or mitochondrial changes.

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