In chronic kidney disease, which failure mode becomes more likely when declining glomerular filtration leads to increased tubular oxalate concentration?

💡 Explanation

Kidney stone formation risk increases because declining glomerular filtration leads to higher oxalate concentrations in the tubules. Supersaturation then favors calcium oxalate crystallization, promoting stone formation, therefore renal calculi become likely, rather than alternative hormonal or electrolyte imbalances.

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