What causes impaired postprandial glucose control when GLP-1 receptor signaling diminishes in pancreatic beta cells?

💡 Explanation

Reduced GLP-1 signaling impairs insulinotropic effects on pancreatic beta cells, resulting in decreased glucose-stimulated insulin secretion, because GLP-1 normally amplifies insulin release. Therefore, blood glucose control diminishes, rather than a problem with hepatic production, glucagon sensitivity, or skeletal muscle uptake.

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