What causes multiple mature follicles to develop during ovarian stimulation for in-vitro fertilization, rather than a single dominant follicle?

💡 Explanation

Ovarian stimulation protocols suppress the normal FSH feedback mechanism, because the body isn't allowed to respond to rising hormone levels. Therefore, multiple follicles mature simultaneously, rather than a single dominant follicle being selected by natural hormonal regulation; inhibin A and estrogen would normally inhibit further FSH release.

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