What distinguishes proteasomal degradation from chaperone-mediated autophagy in intracellular protein clearance?

💡 Explanation

Chaperone-mediated autophagy selectively targets proteins containing a KFERQ-like motif, delivering them to lysosomes for degradation, because proteasomal degradation lacks this selectivity and degrades ubiquitinated proteins nonspecifically; therefore chaperone-mediated autophagy is selective, rather than an ATP-dependent hydrolysis process.

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